METHODS AND COMPOSITIONS FOR THE MODULATION OF CELL INTERACTIONS AND SIGNALING IN THE TUMOR MICROENVIRONMENT

摘要

The present invention is generally directed to identify interacting cells in the tumor microenvironment and using the identified interactions to enhance anti-tumor immunity in cancer. Identified interactions can be modulated using therapeutic agents. Immune cells resistant to suppression can be used for adoptive cell transfer. The present invention is also generally directed to cell types and genes that are correlated to time of tumor growth and tumor size.