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首页> 中文期刊> 《癌症生物学与医学：英文版》 >Mesenchymal stromal cells＇ role in tumor microenvironment：involvement of signaling pathways

Mesenchymal stromal cells＇ role in tumor microenvironment：involvement of signaling pathways

         
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摘要

cqvip:Mesenchymal stromal cells(MSCs) are adult multipotent stem cells residing as pericytes in various tissues and organs where they can differentiate into specialized cells to replace dying cells and damaged tissues. These cells are commonly found at injury sites and in tumors that are known to behave like "wounds that do not heal." In this article, we discuss the mechanisms of MSCs in migrating, homing, and repairing injured tissues. We also review a number of reports showing that tumor microenvironment triggers plasticity mechanisms in MSCs to induce malignant neoplastic tissue formation, maintenance, and chemoresistance, as well as tumor growth. The antitumor properties and therapeutic potential of MSCs are also discussed.

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  • 来源
    《癌症生物学与医学：英文版》 |2017年第2期|P.129-141|共13页
  • 作者

    Armel Herve Nwabo Kamdje; Paul Takam Kamga; Richard Tagne Simo; Lorella Vecchio; Paul Faustin Seke Etet; Jean Marc Muller; Giulio Bassi; Erique Lukong; Raghuveera Kumar Goel; Jeremie Mbo Amvene; Mauro Krampera;

  • 作者单位

    [1]Department of Biomedical Sciences;

    University of Ngaoundere;

    Ngaoundere 454;

    Cameroon [2]Laboratory;

    University of Verona;

    Verona 37129;

    Italy [3]Department of Basic;

    Health Sciences;

    College of Applied Medical Sciences;

    Qassim University;

    Buraydah 52571;

    Saudi Arabia [4]Faculty of Science;

    University of Poitiers;

    Poitiers 86022;

    France [5]Department of Biochemistry;

    College of Medicine;

    University of Saskatchewan;

    Saskatoon S7N 5E5;

    Canada;

    [1]Department of Biomedical Sciences;

    University of Ngaoundere;

    Ngaoundere 454;

    Cameroon [2]Laboratory;

    University of Verona;

    Verona 37129;

    Italy [3]Department of Basic;

    Health Sciences;

    College of Applied Medical Sciences;

    Qassim University;

    Buraydah 52571;

    Saudi Arabia [4]Faculty of Science;

    University of Poitiers;

    Poitiers 86022;

    France [5]Department of Biochemistry;

    College of Medicine;

    University of Saskatchewan;

    Saskatoon S7N 5E5;

    Canada;

    [1]Department of Biomedical Sciences;

    University of Ngaoundere;

    Ngaoundere 454;

    Cameroon [2]Laboratory;

    University of Verona;

    Verona 37129;

    Italy [3]Department of Basic;

    Health Sciences;

    College of Applied Medical Sciences;

    Qassim University;

    Buraydah 52571;

    Saudi Arabia [4]Faculty of Science;

    University of Poitiers;

    Poitiers 86022;

    France [5]Department of Biochemistry;

    College of Medicine;

    University of Saskatchewan;

    Saskatoon S7N 5E5;

    Canada;

    [1]Department of Biomedical Sciences;

    University of Ngaoundere;

    Ngaoundere 454;

    Cameroon [2]Laboratory;

    University of Verona;

    Verona 37129;

    Italy [3]Department of Basic;

    Health Sciences;

    College of Applied Medical Sciences;

    Qassim University;

    Buraydah 52571;

    Saudi Arabia [4]Faculty of Science;

    University of Poitiers;

    Poitiers 86022;

    France [5]Department of Biochemistry;

    College of Medicine;

    University of Saskatchewan;

    Saskatoon S7N 5E5;

    Canada;

    [1]Department of Biomedical Sciences;

    University of Ngaoundere;

    Ngaoundere 454;

    Cameroon [2]Laboratory;

    University of Verona;

    Verona 37129;

    Italy [3]Department of Basic;

    Health Sciences;

    College of Applied Medical Sciences;

    Qassim University;

    Buraydah 52571;

    Saudi Arabia [4]Faculty of Science;

    University of Poitiers;

    Poitiers 86022;

    France [5]Department of Biochemistry;

    College of Medicine;

    University of Saskatchewan;

    Saskatoon S7N 5E5;

    Canada;

    [1]Department of Biomedical Sciences;

    University of Ngaoundere;

    Ngaoundere 454;

    Cameroon [2]Laboratory;

    University of Verona;

    Verona 37129;

    Italy [3]Department of Basic;

    Health Sciences;

    College of Applied Medical Sciences;

    Qassim University;

    Buraydah 52571;

    Saudi Arabia [4]Faculty of Science;

    University of Poitiers;

    Poitiers 86022;

    France [5]Department of Biochemistry;

    College of Medicine;

    University of Saskatchewan;

    Saskatoon S7N 5E5;

    Canada;

    [1]Department of Biomedical Sciences;

    University of Ngaoundere;

    Ngaoundere 454;

    Cameroon [2]Laboratory;

    University of Verona;

    Verona 37129;

    Italy [3]Department of Basic;

    Health Sciences;

    College of Applied Medical Sciences;

    Qassim University;

    Buraydah 52571;

    Saudi Arabia [4]Faculty of Science;

    University of Poitiers;

    Poitiers 86022;

    France [5]Department of Biochemistry;

    College of Medicine;

    University of Saskatchewan;

    Saskatoon S7N 5E5;

    Canada;

    [1]Department of Biomedical Sciences;

    University of Ngaoundere;

    Ngaoundere 454;

    Cameroon [2]Laboratory;

    University of Verona;

    Verona 37129;

    Italy [3]Department of Basic;

    Health Sciences;

    College of Applied Medical Sciences;

    Qassim University;

    Buraydah 52571;

    Saudi Arabia [4]Faculty of Science;

    University of Poitiers;

    Poitiers 86022;

    France [5]Department of Biochemistry;

    College of Medicine;

    University of Saskatchewan;

    Saskatoon S7N 5E5;

    Canada;

    [1]Department of Biomedical Sciences;

    University of Ngaoundere;

    Ngaoundere 454;

    Cameroon [2]Laboratory;

    University of Verona;

    Verona 37129;

    Italy [3]Department of Basic;

    Health Sciences;

    College of Applied Medical Sciences;

    Qassim University;

    Buraydah 52571;

    Saudi Arabia [4]Faculty of Science;

    University of Poitiers;

    Poitiers 86022;

    France [5]Department of Biochemistry;

    College of Medicine;

    University of Saskatchewan;

    Saskatoon S7N 5E5;

    Canada;

    [1]Department of Biomedical Sciences;

    University of Ngaoundere;

    Ngaoundere 454;

    Cameroon [2]Laboratory;

    University of Verona;

    Verona 37129;

    Italy [3]Department of Basic;

    Health Sciences;

    College of Applied Medical Sciences;

    Qassim University;

    Buraydah 52571;

    Saudi Arabia [4]Faculty of Science;

    University of Poitiers;

    Poitiers 86022;

    France [5]Department of Biochemistry;

    College of Medicine;

    University of Saskatchewan;

    Saskatoon S7N 5E5;

    Canada;

    [1]Department of Biomedical Sciences;

    University of Ngaoundere;

    Ngaoundere 454;

    Cameroon [2]Laboratory;

    University of Verona;

    Verona 37129;

    Italy [3]Department of Basic;

    Health Sciences;

    College of Applied Medical Sciences;

    Qassim University;

    Buraydah 52571;

    Saudi Arabia [4]Faculty of Science;

    University of Poitiers;

    Poitiers 86022;

    France [5]Department of Biochemistry;

    College of Medicine;

    University of Saskatchewan;

    Saskatoon S7N 5E5;

    Canada;

  • 原文格式 PDF
  • 正文语种 CHI
  • 中图分类 动物遗传学;
  • 关键词

    基质细胞 肿瘤组织 微环境 信号通路 骨髓间充质干细胞 间质 组织损伤 MSCs;

    机译：基质细胞 肿瘤组织 微环境 信号通路 骨髓间充质干细胞 间质 组织损伤 MSCs;
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