CD4+CD25+调节性T细胞免疫抑制及其在疫苗免疫保护中作用的研究进展

摘要

调节性T细胞(Treg)通过高表达CD25分子在免疫应答过程中发挥免疫抑制功能,其功能是通过下调自身免疫应答诱导自身免疫耐受和自身免疫性疾病的发生.正常情况下Treg与辅助性T细胞17互相拮抗,保持机体平衡.在感染性疾病和自身免疫性疾病中,通过增加Treg可减缓病情.通过去除Treg联合疫苗免疫的策略,有助于提高抗感染和抗肿瘤的疗效.因此,在疫苗免疫保护中,对Treg免疫抑制功能的研究能够为研制新型疫苗奠定理论基础.%Through constitutive expressionr of the CD25 on their surface Treg cells play an impoitant role in the immunosuppression. It functions by down-regulating their autoimmunity response to induce autoimmune toleance and inhibit autmmmunr disease.Normally Treg Th17 are antagomstfi to each other,keeping the body in balance.In infectious diseases and autinmmunr diseases, increasing the Tirg cells could relieve the disease. The strategy of depleting Treg joint vacine immune helps improve resistanre to infection and anti-cancer efficacy. In the vaceine immunr protection, research Treg immunopuppression provides the theoieti-eal basis for developig new vaccines.