佛山地区322例儿童食物不耐受特异性IgG抗体检测结果分析

摘要

Objective:To analyze and evaluate the relationship between food intolerance-specific serum IgG antibody levels and the clinical symptoms in children, explore the food intolerance situation of children in Foshan area. Methods:Enzyme-linked immunmosorbent assay (ELISA) was applied to detect the levels of 14 kinds of food intolerance-specific serum IgG antibodies in 322 patients.Results:The positive rate of patients with symptoms of the skin system was 85.5%(59/69), with digestive symptoms was 85.7%(126/147), with respiratory symptoms was 92.9%(39/42),and with other symptoms was 73. 4%(47/64);Among the 14 kinds of food intolerance-specific IgG antibodies, the positive rate of milk was the highest (68.4%),followed by egg yolk/egg white( 53.11%), cod fish(18.94%),soybean(9.94%),tomatoes(6.83%),rice(6.52%),crab(3.73%),beef(3.73%),wheat(3.11%),pork(2.99%),corn(2.17%),shrimp( 1.86%),chicken(1.55%)and mushroom(0.93%) respectively. Conclusions:Food intolerance might be one of the pathogenic factors of several diseases such as allergic skin disease, respiratory and digestive diseases in children,and milk and eggs were the most common. The detection of food intolerance-specific serum IgG antibodies might be useful for diagnosis, prevention and guiding dietary treatment for children suffering from food allergy.%目的：通过分析儿童血清中食物不耐受特异性IgG抗体水平与临床症状的关系，了解佛山地区儿童食物不耐受情况。方法：应用酶联免疫吸附试验法检测322例患者血清中14种食物特异性IgG抗体水平。结果：322例患儿中，皮肤系统症状患者食物不耐受阳性率为85.5%（59例/69例）；消化系统症状患者阳性率为85.7%（126例/147例）；呼吸系统症状患者阳性率为92.9%（39例/42例）；其他症状患者阳性率73.4%（47例/64例）。14种食物中以牛奶阳性率最高，为68.4%，其余依次为蛋黄/蛋清53.11%，鳕鱼18.94%，大豆9.94%，西红柿6.83%，大米6.52%，蟹和牛肉均为3.73%，小麦3.11%，猪肉2.99%，玉米2.17%，虾1.86%，鸡肉1.55%，蘑菇0.93%。结论：儿童常见的变态反应性皮肤病、呼吸系统及消化系统等疾病可能与食物不耐受有关，并且食物不耐受多以牛奶和鸡蛋为主。根据实验结果对患儿过敏性疾病的诊断、预防及指导饮食治疗有重要临床意义。