目的：：观察血浆游离氨基酸及白细胞介素与抑郁症的关系。方法：选取76例抑郁症患者为观察组，并以同时期的76名健康同龄人为对照组，将两组人员的血浆游离氨基酸及白介素分别检测及比较，同时将观察组中不同抑郁程度的抑郁症者进行比较，并以Logistic分析将检测指标与抑郁症的关系进行分析。结果：观察组的血浆游离氨基酸水平均低于对照组，血浆白介素水平均高于对照组，且轻度、中度和重度抑郁症患者之间也存在明显差异(P<0.05)，但内源性与外源性患者之间无明显差异(P>0.05)，经Logistic分析显示上述血浆检测指标均与抑郁症有密切的关系。结论：与正常人相比抑郁症患者的血浆游离氨基酸偏低而血浆白介素水平偏高，其偏离程度与抑郁症程度呈正湘关。%Objective:To observe the relationships between plasma free amino acids, various interleukins and depression. Methods:76 patients with depression were selected as observation group, while 76 healthy persons with the same age at the same time were used as control group. The plasma free amino acids and various interleukins of the two groups were detected and compared, re-spectively. The plasma detection levels of observation group with different severity degree depression were compared, and then the rela-tionship between these detection indices and depression was analyzed by the Logistic analysis. Results: The plasma free amino acids levels of observation group were lower than those of control group, while plasma interleukins levels were higher than those of control group, and those levels of observation group with mild, moderate and severe depression had obvious differences (P<0. 05);however, the levels of the patients with endogenous depression and exogenous depression had no obvious differences (P>0. 05). These indices all had close relationships with depression by the Logistic analysis. Conclusions:The plasma free amino acids and various interleukins of patients with depression are significantly higher than those of healthy persons, and they deviation degrees are positively correlated with depression degree.
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