抗结核药物导致肝功能损害的影响因素分析

摘要

Objective:To analyze the characteristics and risk factors of hepatic lesion caused by anti-tuberculosis drugs,and to provide evidence for prevention. Method:401 patients with pulmonary tuberculosis registration collected in our hospital from 2005 to 2012,64 cases of liver damage. Clinical features and analysis of related factors such as age,sex,alcohol,TB category,hepatitis B surface antigen carriers were statistically analyzed. Result:In 401 cases,15.96%(64/401)of patients were liver damage,statistics show:HBsAg(+),weekly drinking≥500 g,retreatment,≥60years old in the liver function damage were statistically significant(P<0.05 ),the liver function damage rate were respectively 41.07%(23/56),25.68%(19/74),19.67%(12/61),26.97%(48/178). Sex and drug-induced liver had no significant association(P>0.05). Conclusion:HBsAg(+), alcohol consumption,the retreatment and old TB patients occurr hepatic dysfunction high-risk groups should be in clinical attention.%目的：分析抗结核药物所致肝功能损害的特点及危险因素，为预防提供依据。方法：收集本院2005年1月-2012年12期间登记的肺结核患者401例，其中发生肝功能损害者64例，分析临床特点并对相关因素如年龄、性别、饮酒、肺结核病类别、乙肝表面抗原携带者进行统计学分析。结果：401例患者中，肝功能损害发生率为15.96%（64/401），统计显示：HBsAg（+）、每周饮酒≥500 g、复治、≥60岁的高龄者在肝功能损害中差异有统计学意义（P<0.05），其肝功损害的发生率分别是41.07%（23/56），25.68%（19/74），19.67%（12/61），26.97%（48/178）；而性别与药物性肝损害无显著性关联（P>0.05）。结论：HBsAg（+）、饮酒、复治及高龄的结核病患者是发生肝功能损害的高危人群，在临床中应引起重视。