奥氮平与利培酮治疗系统性红斑狼疮所致精神障碍疗效对照分析

摘要

目的：探讨奥氮平与利培酮治疗系统性红斑狼疮所致精神障碍的疗效及安全性。方法：将64例红斑狼疮所致精神障碍患者随机分为两组，分别予奥氮平及利培酮治疗4周，在治疗前及治疗后1、2、3、4周分别予PANSS量表评定疗效，用TESS量表评定不良反应。结果：治疗1周后奥氮平组患者PANSS评分开始下降，较利培酮组起效快，两组患者疗效比较差异有统计学意义（P<0.01）；奥氮平组不良反应也低于利培酮组，差异有统计学意义（P<0.01）。结论：奥氮平与利培酮对红斑狼疮所致精神障碍均有效，而奥氮平起效更快，不良反应较少，更适合红斑狼疮所致精神障碍患者。%Objective:To investigate the efficacy and safety of Olanzapine and Risperidone on mental disorder caused by lupus erythema.Method: 64 patients with mental disorders due to systemic lupus erythematosus were divided into two groups,they were treated with Olanzapine and Risperidone for 4 weeks.The efficacy before treatment and after treatment 1week, 2, 3, 4 weeks were evaluated by PANSS scale,the adverse reactions were evaluated by TESS scale.Result:After treatment for 1 week,PANSS scores of the Olanzapine group were dropped significantly,the effect was faster than the Risperidone group,the curative effect difference of the two groups was statistically significant (P<0.01). The adverse reactions of the Olanzapine group were lower than those of the Risperidone group, the differences were statistically significant (P<0.01).Conclusion: Olanzapine and Risperidone on mental disorders caused by lupus erythematosus are effective, and Olanzapine work faster, with less adverse reaction, more suitable for patients with mental disorder caused by lupus erythematosus.