ω-3多不饱和脂肪酸对脓毒症患者氧化应激及免疫状态的影响研究

摘要

Objective:To explore the oxidative stress and immune status impact study on sepsis patients byω-3polyunsaturated fatty acids.Method:Patients were randomly divided into observation group and control group, 30 cases in each group.Two groups of patients were accepted nutrients such as nitrogen, such as heat all-in-one parenteral nutrition support and the corresponding conventional treatment, continuous for 7 d.Which controls provided by the long chain fatty milk 20%, observation group by omega-3 polyunsaturated fatty acid + 20% long chain fatty milk.Before and after treatment oxidative stress response and immune function changes of the related indexes were compared of the two groups, and make analysis summary.Result:The observation group in the eighth day after the treatment of inflammation and immune indexes improved than the control group significantly (P<0.05), oxygen stress index, plasma lipid peroxides LOP, serum MDA declined significantly,serum glutathione GSH was increased after treatment (P<0.05), oxidative stress response to effective control.Conclusion:Omega-3 PUFAs can improve the immune function of patients with sepsis, reduce inflammation, effective control of oxidative stress reaction.%目的：探究ω-3多不饱和脂肪酸对脓毒症患者氧化应激及免疫状态的影响。方法：将患者按随机数字表法分为观察组和对照组，每组各30例。两组患者均接受等氮、等热量全合一营养液肠外营养支持以及相应的常规治疗，连续7 d。其中对照组脂肪由20%中长链脂肪乳制剂提供，观察组脂肪由ω-3多不饱和脂肪酸+20%中长链脂肪乳提供。观察比较两组治疗前后氧化应激反应、免疫功能等相关指标的变化情况，并做出分析总结。结果：观察组在治疗后第8天炎症反应及免疫指标较对照组均改善明显（P<0.05），血浆脂质过氧化物LOP、血清MDA在治疗后显著下降，血清谷胱甘肽CSH上升（P<0.05），氧化应激反应得到了有效控制。结论：ω-3 PUFAs可改善脓毒症患者免疫功能，减轻炎症反应，有效控制氧化应激反应的发生。