他汀类药物对高LDL－C血症伴房颤患者血清hs－CRP的影响

摘要

Objective:To study the effect of statin therapy on serum hs-CRP level of patients with high LDL-C in atrial fibrillation(AF) and its clinical significance. Methods: 114 high LDL-C patients with AF were classified as AF group, 55 high LDL-C patients with sinus rhythm (SR) were classified as SR group, and they were divided into SR with statin therapy group (n=27) and SR without statin therapy group (n=28), AF without statin therapy group (n=55) and AF with statin therapy group (n=59) according to with or without statin therapy. The levels of serum hs-CRP were compared among the groups. Results: The serum hs-CRP level in AF without statin therapy group was significantly higher than that of the SR without statin therapy group (P<0.05),and the serum hs-CRP level in SR patients did not reveal any significant differences between with and without statin therapy (P>0.05). The serum hs-CRP level in AF with statin therapy group was significantly lower than that in AF without statin therapy group (P<0.05). Conclusions:The findings of this study suggest that statin may be very effective in decreasing serum levels of hs-CRP in high LDL-C patients with AF.%目的：探讨他汀类药物对高LDL－C血症伴心房颤动患者血清hs－CRP的影响及临床意义。方法：以高LDL－C血症伴房颤的114例患者作为房颤组，高LDL－C血症窦性心律的55例患者为窦律组，根据是否使用他汀类药物治疗分成窦律非治疗组27例、窦律治疗组28例、房颤非治疗组55例和房颤治疗组59例，比较各组血清hs－CRP。结果：房颤非治疗组血清hs－CRP显著高于窦律非治疗组（P＜0．05）；窦律组内血清hs－CRP差异无统计学意义（P＞0．05）；房颤治疗组血清hs－CRP明显低于房颤非治疗组（P＜0．05）。结论：高LDL－C血症伴房颤患者血清hs－CRP升高，他汀类药物治疗可降低高LDL－C血症伴房颤患者血清hs－CRP水平。