蜕膜自然杀伤细胞在正常妊娠中作用的研究进展

摘要

Decidual natural killer (dNK) cells accumulate in the maternal decidua during pregnancy and are directly in close contact with fetal trophoblasts.However,the mechanisms of dNK cells affecting pregnancy are still unknown.By secreting cytokines/chemokines and angiogenic factors,dNK cells participate in normal placentation with feto-matenal tolerance,spiral artery remodeling and neovascularization during decidualization in a successful pregnancy.Here,the researches about the effect of dNK cells on the development of pregnancy are reviewed.%蜕膜自然杀伤(decidual natural killer,dNK)细胞是存在于母胎界面并与胎儿滋养层细胞密切接触的免疫细胞.近年来的研究发现,正常妊娠过程离不开dNK细胞分泌的相关因子的作用,如母胎耐受、子宫螺旋动脉重铸、血管形成等.现主要综述了近年来dNK细胞参与子宫螺旋动脉重铸及血管形成等方面的研究,以及dNK在维持正常妊娠中的可能作用机制.