巨细胞病毒包膜糖蛋白 B、H、N 及其基因型的研究进展

摘要

巨细胞病毒（CMV）感染在人群当中非常普遍，大多数 CMV 感染为无症状感染，但有症状的 CMV 感染可在儿童中引起严重后遗症。CMV 包膜糖蛋白是病毒最外层的脂质双层包膜的主要成分，对于病毒进入细胞以及病毒的扩散有重要的作用。文章针对 CMV 3种包膜糖蛋白[糖蛋白 B（gB）、糖蛋白 H（gH）和糖蛋白 N （gN）]各自的基因亚型与疾病相关性的国内外研究现状和进展作一综述，期望为 CMV 的研究提供新的思路。%Cytomegalovirus(CMV)infections are very common in human beings. Most of the CMV infections are asymptomatic,however,symptomatic CMV infections in children can cause serious complications. CMV envelope glycoprotein is the main component of the outermost lipid bilayer membrane of CMV and plays an important role in CMV entry and spread between cells. The current situation and prospect of the relationship between gene subtypes and 3 envelope glycoproteins [glycoprotein B(gB),glycoprotein H( gH )and glycoprotein N( gN )] are reviewed and summarized in this review,in order to provide new ideas for CMV studies.