目的 观察重组人生长激素(rhGH)配合相关营养支持对急性呼吸窘迫综合征(ARDS)患者相关蛋白质代谢指标、炎性反应指标、免疫功能指标及血气分析指标的影响.方法 以首都医科大学附属北京潞河医院收治的82例ARDS患者作为研究对象,按随机数字表法分为对照组和观察组,每组41例.对2组患者治疗前后的蛋白质代谢指标血清转铁蛋白(T RF)、血清清蛋白(ALB)、前清蛋白(PAB),炎性反应指标血清肿瘤坏死因子(TNF)-α、白细胞介素(IL)-1、IL-6,免疫功能指标免疫球蛋白(Ig)A、IgG、IgM,以及血气分析指标pH值、动脉血氧分压(PaO2)和动脉血二氧化碳分压(PaCO2)进行监测并作比较.结果 观察组ARDS患者治疗后的蛋白质代谢相关指标T RF、A LB和PAB水平,炎性反应相关指标T N F-α、IL-1和IL-6,免疫功能相关指标IgA、IgG和IgM,血气分析相关指标pH值、PaCO2和PaO2均明显优于治疗前,并且优于对照组治疗后,差异均有统计学意义(P<0.05).结论 rhGH配合营养支持治疗ARDS患者,可明显提升患者血氧水平,降低相关因子的炎性反应,促进患者机体相关蛋白质合成,改善患者蛋白质代谢情况,同时可提升机体体液免疫及细胞免疫功能,对改善A RDS患者生活质量和预后均有重要的意义.%Objective To observe the effect of recombinant human growth hormone(rhGH)cooperate with relevant nutrition support on protein metabolism,inflammatory reaction,immune function and the influ-ence of blood gas analysis index in patients with acute respiratory distress syndrome(ARDS).Methods A to-tal of 82 ARDS patients in Luhe Hospital Affiliated to Capital Medical University were recruited as objects in this research,according to the random number table method,all the objects were divided into control group and observation group,41 patients in each group.Before and after treatment,protein metabolism index inclu-ding serum transferrin(TRF),serum albumin(ALB)and prealbumin(PAB),inflammatory reaction index in-cluding serum tumor necrosis factor(TNF)-α,interleukin(IL)-1,IL-6,immune function index including im-munoglobulin(Ig)A,IgG,IgM,blood gas analysis index including pH,PaO2,PaCO2were monitored and com-pared.Results After treatment,TRF,ALB,PAB,TNF-α,IL-1,IL-6,IgA,IgG,IgM,pH,PaCO2,PaO2in the observation group were significantly better than those in the control group(P<0.05).Conclusion RhGH combined with nutrition support for treating patients with ARDS could obviously improve patients'blood oxy-gen content,reduce the related factors of inflammatory reaction,promoting the patient body protein synthesis, protein metabolism,at the same time improve the cellular immune function and humoral immunity,improve the quality of life and prognosis.
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