[Objective] The purpose of this research is estimating the effects caused by donkey -hide gelatin, chalybeate on the cochlea of the iron deficient hearing-loss rats, and judge which is better by testing the concentration of SOD in cochlea.[Method] Select 40 Wistar rats with normal hearing, 50% females to 50% males, normal diet as control (10 )group, use the forage without iron to build iron deficient deafness animal model (30), then test their DPOAE to screen the very one which is deaf after 6 weeks feeding, and 15 ones with hearing damage are selected out Then divide them into three groups: model group, chalybeate group and donkey-hide gelatin group, and feed with no medicine, chalybeate, donkey-hide gelatin at the random forage. After 3 weeks, test serum SOD, untreated with model group. [Result] Compare model group with control group, the result has significant change (P<0.0l), and compared with model group, both donkey-hide gelatin group and chalybeate group have statistically significant difference (P<0.05),but there is no obvious difference in the side comparison of the chalybeate group and donkey-hide gelatin group(P>0.05).[Conclusion] Both donkeys-hide gelatin and chalybeate have the same effect in reconditioning the hearing of iron deficient hearing loss by changing the volume of SOD.%[目的]本实验通过对阿胶、铁剂对缺铁性聋大鼠耳蜗SOD含量的比较,探究阿胶与铁剂在耳蜗损伤修复功能方面的机制.[方法]选听力正常Wistar大鼠40只,雌雄各半,10只喂饲普通饲料作为对照组,30只喂饲缺铁饲料建立缺铁性聋动物模型,饲养6周后通过检测DPOAE筛选出15只造模成功的大鼠,分成模型组、铁剂组和阿胶组3组,在原有饲料的基础上分别做不给药、给铁剂、给阿胶处理,3周后检测动物血清SOD,未处理组为模型组.[结果]对照组与模型组比较有显著性差异(P＜0.01),阿胶组、铁剂组与模型组比较差异均有统计学意义(P＜0.05),阿胶组与铁剂组比较无显著性差异(P＞0.05).[结论]缺铁能导致SOD含量的减少,阿胶、铁剂能通过改变SOD含量来改善缺铁性聋大鼠的听力情况,其作用效果与铁剂无明显差别.
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