Acute Electrophysiological and Morphological Effects of Mechanical Trauma in the Guinea Pig Cochlea.

摘要

Small mechanical lesions were made in the external wall of the guinea pig cochlea. The effect of the lesion was studied electrophysiologically and with histopathological techniques for the investigation of vessels and sensory and supporting structures. The methodological approach seems promising. The restricted lesions resulted in restricted change of both the electrophysiology and morphology of the cochlea. Quantitative and orderly changes between size and location of lesion and cochlear activity were not found. In these short-term experiments, no morphological effect was seen on the organ of Corti. The injury was limited to a narrow segmental area of the external wall with major influence on the vessels here. (Author)