创伤性休克复苏研究的挑战与机遇:大数据分析、计算机科学、系统生物学与创伤科学的融合

摘要

Further improvement of traumatic shock resuscitation research faces some insurmountable barri — ers.Recent developments in data analysis ,computational science and systematic biology techniques offer an inte — grated approach to overcome these barriers.As a frontier technique ,computer — assist clinical decision support sys — terns (CDCSS) provide a unique opportunity for improving accuracy and quality of clinical diagnosis and treatment.In addition,CDCSS is becoming a universal research and development platform for individualized medicine.As part of this evolution ,there are several CDCSS tools that have been developed.They have been used for outcome predic — tion for severe trauma patients ,and to help clinicians determine the appropriate target for resuscitation.Developing the next generation of CDCSS is a coming tide in trauma research.To achieve this goal ,we need to establish multi-disciplinary,physician-scientist teams versed in translational medicine.%传统临床科研格局下的创伤休克救治研究,面临仅靠自身难以突破的障碍.但随着近年来大数据挖掘、计算机科学以及系统生物医学技术的快速发展,提高创伤休克救治水平的多学科研究方向已经确立,整个创伤科学研究的未来必然是向融合多学科技术工具和平台的道路前进,尤其是引入计算机辅助的临床决策支持系统(computerized clinical decision support system,CDCSS).CDCSS是近十年来随着计算机科学的快速进步而发展起来的临床诊疗新工具.作为融合了计算机和人工智能的崭新技术,CDCSS目前已经成为帮助临床医学各个学科提高诊疗水平的利器,并正在成为下一代个性化医疗技术发展的基础平台.在创伤休克诊疗上,已有的CDCSS聚焦于帮助临床医师对不同预后类型的患者进行预判,并决定适当的复苏终点.从提高研究水平的角度,创伤复苏研究的未来发展,应当遵循转化医学的要求,建立多学科的医生科学家团队及相应研究机构,促进科技创新成果向临床技术转化.