CCR7生物学轴在原发性肝癌形成中的作用研究进展

摘要

Chemokines belong to the family of cytokines and their receptors belong to G⁃protein coupled receptors. The role of chemokines and their receptors in the initiation and development of primary hepatic carcinoma ( hereafter referred to as a hepatic carcinoma) has been widely concerned in recent years. The study found that, CCR7 is closely related to the initiation, develop⁃ment, treatment and prognosis of disease. This paper will make the following discussion about the role of chemokines in the initia⁃tion and development of hepatic carcinoma.%目的：趋化因子属于细胞因子家族，其受体属于G蛋白偶联受体。近年来，趋化因子及其受体在原发性肝癌（以下简称肝癌）发生、发展中的作用逐渐受到广泛关注。研究发现，趋化因子受体CCR7与疾病的发生、发展、治疗及预后密切相关。本研究就趋化因子受体CCR7在肝癌发生、发展过程中的作用作如下综述。