LM23 may regulate the G1/S and G2/M transitions of the cell cycle in rat spermatogenesis

摘要

Objective:LM23（AF492385） is a gene specifically expressed in the testis of Rattus norvegicus previously reported by our laboratory.The aim of the study is to further investigate its biological function. Methods:Bioinformatic tools were utilized,including Protfun server and CPHmodles.The biological functions of LM23 were analyzed with microarray analysis,using a rat model of LM23 gene knock-down. Results:Protfun server shows that LM23 is likely a growth factor or Lyase.LM23 is more likely involved in regulatory functions of translation.The expressions of some genes related to the cell cycle were significantly changed after LM23 knock-down,as shown by microarray analysis. Conclusions:LM23 may regulate the G1/S and G2/M transitions of the cell cycle during spermatogenesis.