胃癌患者手术前后血清IGF-Ⅱ、TGF-α和TNF-α检测的临床评价

摘要

目的:探讨胃癌患者手术前后血清IGF-Ⅱ、TGF-α和TNF-α水平的变化及临床意义.方法:应用放射免疫分析对31例胃癌患者进行了手术治疗前后血清IGF-Ⅱ、TGF-α和TNF-α检测,并与35名正常健康人作比较.结果:胃癌患者在手术治疗前血清IGF-Ⅱ、TGF-α和TNF-α水平非常显著地高于正常人组(P0.05).结论:检测胃癌患者血清IGF-Ⅱ、TGF-α和TNF-α水平的变化可作为疗效观察的指标.%Objective To explore the significance of changes of serum IGF- Ⅱ ,TGF-α and TNF-α levels both before and after operation in patients with gastric cancer . Methods Serum IGF- Ⅱ ,TGF-α and TNF-α levels were determined with RIA in 31 patients with gastric cancer and 35 normal healthy controls. Results Before operation,the serum IGF-Ⅱ ,TGF-α and TNF-α levels in the patients were significantly higher than those in the controls(P >0.05). Conclusion Serum levels of IGF-Ⅱ ,TGF-α and TNF-α might be useful as an indicator for predicting therapeutic efficacy after operation in patients with gastric cancer.