Objective To detect the expression of ITGB1 in the serum and placenta of pregnant women with preeclampsia and its clinical significance. Methods A total of 150 pregnant women with sever or mild pre-eclampsia and normal pregnant women were collected. The expression change of ITGB in the serum and placenta was detected by real-time PCR. The correlation between the expression of serum ITGB1 and clinical symptoms in normal pregnant women and pregnant women with preeclampsia was explored. Results There was significantly high expression of ITGB1 in the serum and tissue of patients with preeclampsia and placenta and the expression of ITGB1 in patients with preeclampsia and normal pregnant women was positively correlated (P = 0.011). The expression level of serum ITGB1 was positively correlated with systolic blood pressure,diastolic blood pressure,24 h urine protein and vascular disease. Serum ITGB1 was used as a diagnostic marker for preeclampsia,with an AUC of 0.751 ,a specificity of 81% and a sensitivity of 75%. Conclusion ITGB1 is involved in the occurrence and development of preeclampsia,and is positively correlated with clinical symptoms. The expression of serum ITGB1 can be used to predict the occurrence of preeclampsia.%目的 检测子痫前期孕妇血清以及胎盘组织中ITGB1的表达中并探讨其临床意义.方法 选取轻度子痫前期以及重度子痫前期孕妇各50例,另选择与其相匹配的正常孕妇50例作为对照组,运用荧光定量PCR技术检测ITGB在胎盘以及血清中的表达变化.Pearson相关性分析正常孕妇以及子痫孕妇的ITGB1的相关性,探讨血清ITGB1的表达与临床症状的相关性以及预测价值.结果 子痫前期患者中血清以及胎盘组织中的ITGB1均明显高表达,子痫前期患者与正常孕妇中ITGB1的表达呈正相关(P=0.011).血清ITGB1的表达量与患者的收缩压、舒张压、24 h尿蛋白以及眼底血管疾病呈正相关.血清ITGB1作为子痫的诊断曲线下面积为0.751,特异度为81%和灵敏度为75%.结论 ITGB1参与到子痫的发生发展过程中并且与临床症状呈正相关,血清ITGB1的表达可作为预测子痫的发生,具有良好的预测价值.
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