戈舍瑞林对绝经前乳腺癌患者卵巢功能的保护作用

摘要

Objective To investigate the effect of Goserelin in protection of the ovarian function of pre-menopausal breast cancer patients. Methods Eighty premenopausal patients with breast cancer randomly divided equally into study group and control group. The two groups were compared in terms of the menstrual status and the levels of E2,FSH,LH before and after chemotherapy. Results The menstrual recovery rates of the study group and the control group were 90% and 57.5%,respectively ,with statistically significant difference between them (P = 0.018). In the study group,the serum E2 decreased gradually to the postmenopausal level,and the serum levels of FSH and LH were also significantly decreased during the treatment. While in the control group ,the E2 levels gradually decreased ,but the levels of FSH and LH significantly increased during the chemotherapy. Conclusions Goserelin can effectively prevent the injury of ovarian function caused by chemotherapy.%目的 观察绝经前乳腺癌患者辅助化疗期间使用戈舍瑞林对卵巢功能的保护作用.方法 收集80例绝经前乳腺癌患者,随机分为研究组和对照组,每组40例.观察2组患者治疗前后闭经情况及月经复潮情况,比较治疗前后血清雌二醇(E2)、卵泡刺激素(FSH)及黄体生成素(LH)水平的变化.结果 研究组与对照组月经复潮率分别为90%和57.5%,差异有统计学意义.研究组在治疗期间,血清雌二醇(E2)水平逐步下降至绝经后水平,卵泡刺激素(FSH)及黄体生成素(LH)水平也均明显降低;对照组在治疗期间血清雌二醇(E2)水平逐步下降,卵泡刺激素(FSH)及黄体生成素(LH)水平则明显上升.结论 绝经前乳腺癌患者辅助化疗期间使用戈舍瑞林,可有效地保护患者卵巢功能,增加月经复潮的比率,并缩短正常月经恢复时间.