巨细胞病毒感染合并播散性单纯疱疹病毒感染一例

摘要

巨细胞病毒（CMV）合并播散性单纯疱疹病毒（HSV）感染往往发生于HIV感染的患者，HIV阴性患者少见。该文报道1例肾病患者给予糖皮质激素治疗导致CMV和HSV重新激活，给予伐昔洛韦、更昔洛韦、亚胺培南、利奈唑胺等抗感染治疗后CMV-DNA复制数降至正常，皮疹有好转，但50 d后因并发重症免疫抑制宿主肺炎、Ⅰ型呼吸衰竭死亡。该例提示CMV合并播散性HSV感染预后差，应引起临床重视。%Cytomegalovirus (CMV)coinfecting with herpes simplex virus (HSV)usually occurred in patients with human immunodeficiency virus (HIV)infection,while rarely occurred in patients with negative HIV and haven't been reported in mainland China to our best knowledge. We presented an immunocompromised patient with renal disorder treated with corticosteroid resulting in reactivation of CMV and HSV. The CMV-DNA replication number of the patient was reduced to the normal level by valacyclovir,ganciclovir,imipenem,lin-ezolid. Howeve the patient die in the 50th day,who dead for severe complications of pneumonia. We should pay more attention to the disease because of its poor prognosis.