免疫球蛋白样转录子3研究进展

摘要

免疫球蛋白样转录子3 (ILT3)是ILT超家族中的抑制性受体,特异性表达于单核细胞、巨噬细胞和树突状细胞等,通过免疫受体酪氨酸抑制基序(ITIM)传导抑制信号,发挥免疫抑制作用.该文主要综述ILT3对免疫细胞、肺癌、胃癌、卵巢癌、白血病、心脏和胰岛等器官移植以及自身免疫性疾病的影响,并探讨影响ILT3表达的因素,以期为ILT3进一步的研究与开发应用提供理论依据.%Immunoglobulin-like transcript 3 (ILT3)is an inhibitory receptor of the immunoglobulin-like transcript (ILT)superfamily,which specifically expressed in monocytes,macrophages and dendritic cells, etc. ILT3 exerts an immunosuppressive effect through the suppressive signal transduced by immunoreceptor tyrosine-based inhibitory motif (ITIM). This article reviews the effect of ILT3 upon immune cells,lung canc-er,gastric cancer,ovarian cancer,leukemia,organ transplantation such as heart and islets,and autoimmune diseases. The influencing factors of ILT3 expression is also investigated,aiming to provide theoretical basis for further research and development of ILT3.