血清肝纤四项检测在原发性肝癌诊断中的应用

摘要

Objective To investigate the application of 4 serum liver fibrosis biomarkers in the diagnosis of hepatic cancer . Methods The levels of serum protein collagen Ⅲ( PCⅢ) , collagenⅣ(Ⅳ-C) , Laminin ( LN) and hyaluronic acid ( HA) were de-tected by ECLI in 46 cases of primary cancer , 51 cases of metastatic liver cancer , 46 cases of extra-hepatic malignant tumor and 50 health examinees .Results The levels of PCⅢ,Ⅳ-C, LN and HA in the patients of the primary liver cancer group were all higher than those of the metastatic liver cancer group and the extra-hepatic malignant tumor group (P<0.05) , and the detected data of the above 3 groups were all significantly higher than those of the control group (P<0.01).Conclusion The 4 serum liver fibrosis biomarkers were closely associated with primary liver cancer , and the detection of the 4 serum liver fibrosis biomarkers was valuable to the judgment of the seriousness of hepatic fibrosis in primary liver cancer and the identification of metastatic liver cancer .%目的：探讨血清肝纤4项检测在原发性肝癌诊断中的应用。方法采用化学发光法检测46例原发性肝癌、51例转移性肝癌、46例肝外恶性肿瘤患者和50名健康体检人员血清Ⅲ型前胶原（ PCⅢ）、Ⅳ型胶原（Ⅳ-C）、层粘连蛋白（ LN）和透明质酸（HA）的含量。结果原发性肝癌组PCⅢ、Ⅳ-C、LN和HA水平高于转移性肝癌组和肝外恶性肿瘤组（P＜0．05），且三者都明显高于健康对照组（ P＜0．01）。结论肝纤4项指标与原发性肝癌关系密切，血清肝纤4项检测对原发性肝癌肝纤维化程度的判断、鉴别转移性肝癌有一定的价值。