胃癌及癌前病变中MGMT的表达及其意义

摘要

目的:探讨DNA 损伤修复基因产物-MGMT在胃癌及癌前病变中的表达及其意义.方法:采用免疫组化SP法检测MGMT在62例胃癌和42例胃黏膜异型增生组织中的表达.结果:MGMT蛋白在正常胃黏膜、轻度异型增生胃黏膜、中重度异型增生胃黏膜、 早期胃癌、进展期胃癌中的阳性表达率分别为93.8%、94.4%、91.7%、66.7%、68.2% .MGMT蛋白在轻度异型增生胃黏膜的表达率明显高于早期胃癌及进展期胃癌(P<0.05);在中重度异型增生组中的表达率高于早期胃癌(P<0.05).胃癌中MGMT表达与分化程度、淋巴结转移相关(P<0.05).结论:MGMT基因可能在胃癌发生中起重要的作用,可能成为监测胃黏膜早期癌变及判断胃癌生物学行为的有用指标.%Objective : To study the Livin, Ki - 67 expression in gastric cancer in and its clinical significance. Methods: To detemune Livin, Ki -67 in 40 cases of gastric cancer by immunohistochemistry. Results : Livin and Ki - 67 were related to lymph node metastasis, ( P ＜ 0. 05 ) ;on relation with gender, age . depth of invasion , clinical stages (P ＞ 0. 05 ). Livin, Ki -67 expression in gastric cancer was not related ( P ＞ 0. 05). Condusion: Livin, Ki - 67 may help determine the degree of malignancy of gastric cancer and the progress of gastric cancer.