软组织骨化性纤维黏液样瘤临床病理观察

摘要

目的：探讨软组织骨化性纤维黏液样瘤（ ossifying fibromyxoid tumor，OFMT）临床病理学特征、诊断及鉴别诊断。方法：结合文献对2例骨化性纤维黏液样瘤患者的临床表现、组织形态学特点、免疫组化、组织来源和预后进行探讨。结果：骨化性纤维黏液样瘤有纤维性包膜及不连续的骨壳，肿瘤实质呈大小不一的小叶状结构，细胞密度不均，瘤细胞间为多少不等的纤维黏液样基质。免疫组化肿瘤细胞表达Vim、GFAP、CD99、NSE。结论：软组织骨化性纤维黏液样瘤少见，易误诊，主要依据其典型的镜下形态并结合免疫组化做出诊断。免疫组化结果支持OFMT雪旺细胞起源。%Objective:To study the clinical and pathologic features,diagnosis and differential diagnosis of ossifying fibromyxoid tumor. Methods:The clinical manifestations,histopathological featrures,immunohistochemistry,histogene-sis and prognosis were analyzed in two cases of ossifying fibromyxoid tumor with review of the literatures. Results:Os-sifying fibromyxoid tumor was encapsulated with an incomplete of bone within the capsule in most cases. The tumor parenchyma consisted lobules of variable size and cellularity,with myxiod and/or fibrous stroma. Immunophenotypes showed that the tumor was positive to Vim,GFAP,CD99 and NSE. Conclusion:OFMT is rare and easily misdiag-nosed. Its diagnosis mainly bases on the characteristics of histopathology and immunohistochemistry. Immunohisto-chemical result supported a Schwann-cell origin.