宫颈癌术后适形调强放疗、旋转调强放疗与三维适形放疗的疗效分析

摘要

Objective:To study the survival rates and side effects of RapidArc,intensity -modulated radiotherapy (IMRT)and 3 -dimensional conformal radiotherapy(3D -CRT)for early stage postoperative cervical cancer with high risk factors.Methods:To analyze retrospectively 110 cases of early stage cervical cancer patients with risk factors and postoperative radiotherapy in our hospital,which 58 cases of IMRT group,10 cases of RapidArc,42 cases of 3D -CRT.Results:IMRT and RapidArc group significantly decreased adverse reactions compared with 3D -CRT group,P<0.05),while there were no significant difference on 1 -and 2 -year overall survival rates among 3D -CRT,IMRT and RapidArc group (P >0.05).Adverse reactions and survival rate of IMRT group and RapidArc group were similar (P >0.05).Conclusion:Our results suggest that adjuvant radiotherapy 3D -CRT,IMRT and RapidArc in early stage postoperative cervical cancer with high risk factors have similar survival rate,but 3D -CRT and IMRT have lower tox-icity.It is also confirmed that RapidArc and IMRT have no significant differences in survival rate and adverse reac-tions.%目的：比较有高危因素的早期宫颈癌患者术后，调强放疗（intensity －modulated radiotherapy，IMRT）、旋转调强放疗（RapidArc）和三维适形放疗（three －dimensional conformal radiotherapy，3D －CRT）的疗效及不良反应。方法：回顾分析本院接受术后放疗的110例具有高危因素的早期宫颈癌患者，其中 IMRT 组58例， RapidArc 组10例，3D －CRT 组42例，比较三种治疗方法的疗效及不良反应。结果：IMRT 组和 RapidArc 组的不良反应明显低于3D －CRT 组，差异有统计学差异（P ＜0．05），但三组1、2年生存率无明显差异（P ＞0．05）；RapidArc 组与 IMRT 组的不良反应及生存率均无统计学差异（P ＞0．05）。结论：对于具有高危因素的早期宫颈癌患者，其术后辅助放疗，采用 RapidArc、IMRT 不良反应的发生率明显低于3D －CRT；RapidArc 和IMRT 在生存率及不良反应方面无明显差异。