AKt／mTOR 信号通路中 p70S6K1、4E －BPs 在促进肿瘤发生作用中的研究进展

摘要

当受细胞外生长因子等刺激作用后，可激活 PI3K／AKt／mTOR 信号通路，参与控制细胞的生长、增殖、生存、凋亡。AKt／mTOR 信号通路在肿瘤的发生发展过程中起着很重要的促进作用。AKt／mTOR 信号通路在肿瘤细胞中能够通过 p70S6K1和4E －BPs 的作用抑制细胞的凋亡，促进核糖体以及蛋白质的合成、促进肿瘤细胞的侵袭和转移、促进细胞周期进展、促进肿瘤血管的生成，进而促进肿瘤的发生发展。本文就AKt／mTOR 信号通路通过 p70S6K1和4E －BPs 促进肿瘤发生的机制进行综述。%The PI3K/AKt/mTOR signal pathway can be activated when cells are stimulated by growth factors to con-trol the growth,proliferation,survive and apoptosis of the cells.AKt/mTOR signaling pathways plays an important role in promoting the development process of tumor.AKt/mTOR signal pathway can inhibit apoptosis in tumor cells,pro-mote the invasion and metastasis of tumor cells,the cell cycle progression and the formation of tumor blood vessels to promote the occurrence of tumor via p70S6K1 and 4E -BPs.In this paper,the mechanism of how the AKt/mTOR sig-naling pathway facilitate the formation of tumors through p70S6K1 and 4E -BPs was reviewed.