肾细胞癌的新辅助治疗

摘要

Metastatic-renal-cell-carcino-ma-can't-be-cured-by-the-existing-vari-ous-syste-mic-treat-ment-.Surgery-is-the-onl-y-means-to-cure-ki-dney-cancer-.Nephrectomy-in-still-plays-an-i-mportant-role-in-the-treat-ment-of-metastatic-ki-d-ney-cancer-,the-emergence-of-targeted-drugs-provi-des-a-ne-w-choice-for-ki-dney-cancer-treat-ments-.Current-issue-of-preoperati-ve-neoadj-uvant-applicati-ons-of-targeted-therapy-incl-udes-treat-ment-indicati-ons-,drug-safety-and-therapeutic-effects-of-expectati-ons-,and-the-best-treat-ment-durati-on-.This-revie-w-focuses-on-the-foll-o-wing-t-wo-questi-ons-:①The-preoperati-on-ad-miniatrati-on-of-neoadj-uvant-targeted-therapy-for-advanced-ki-dney-cancer-patients-have-a-reasonable-theoretical-basis---What-type-of-clinical-data-(case-report-,Ⅱ/Ⅲclinical-trials-)support-this-indicati-ons---②What's-the-indicati-ons-and-the-safety-eval-uati-on-of-ne-w-adj-uvant-target-therapy-%现有的各种全身治疗方式不能治愈转移性肾癌。外科手术是治愈肾癌的唯一手段。减瘤性肾切除术在转移性肾癌治疗中仍然扮演着重要角色,靶向治疗药物的出现为肾癌治疗方式提供了新的选择。目前关于手术前新辅助应用靶向治疗的问题主要包括治疗适应症,用药安全性,治疗效果的预期,最佳治疗持续时间三方面。该综述主要讨论以下两个问题：①晚期肾癌患者术前应用靶向药物进行新辅助治疗是否有合理的理论依据？什么类型的临床数据(病例报告,Ⅱ/Ⅲ期临床试验)支持上述指征？②应用新辅助治疗的指征及治疗安全性如何评价？