手推注射减量稀释钆对比剂在垂体MRI动态增强扫描中的应用

摘要

Objective To compare the perfection of reduced-dose gadoteric acid (0.07 mmol/kg gadoteric acid diluted with 0.15 ml/kg normal saline) rejected manually with traditional half dose gadoteric acid (0.05 mmol/kg) rejected by a high pres-sure rejector in dynamic contrast enhanced pituitary magnetic resonance ( MR) imaging.Methods In this randomized study , 45 volunteers consecutively underwent dynamic contrast enhanced pituitary MR imaging were rejected either reduced -dose and diluted gadoteric acid manually (22 cases) or half dose gadoteric acid by a high pressure rejector (23 cases).The enhancement effects and the margin between pituitary and cavernous sinus were evaluated .Then 153 consecutive patients suspected pituitary diseases were randomly received reduced-dose and diluted gadoteric acid rejected manually (79 cases) or half dose gadoteric acid rejected by a high pressure rejector (74 cases) during dynamic contrast enhanced pituitary MR imaging .And the detection rates and the margins of the lesions were assessed .Results High degree of enhancement was observed in all volunteers getting a peak of en -hancement within about one minute .The second group got a higher degree of enhancement than the first group ( P <0.05), while the scores of the margin between pituitary and cavernous sinus were close between two groups ( P =0.085).The detection rates ( P =0.787) and the scores of the lesion margins ( P =0.682) were similar between two patients groups as well .Conclu-sion Reduced-dose and diluted gadoteric acid rejected manually gets a similar performance to traditional half dose gadoteric acid rejected by a high pressure rejector in dynamic contrast enhanced pituitary MR imaging .%目的 研究减量稀释钆对比剂在垂体MRI动态增强扫描中的应用效果. 方法 连续性将45例志愿者随机分成2组,其中甲组22例采用减量稀释对比剂( 0 .07 mmol/kg钆喷酸葡胺与0 .15 ml/kg生理盐水混合)进行手推注射动态增强扫描,乙组23例采用半剂量(0.05mmol/kg)钆喷酸葡胺双筒高压注射器进行动态增强扫描,比较2组间垂体强化的特点、垂体与海绵窦之间的分界. 然后连续性将153例疑有垂体病变的患者随机分成2组进行MRI动态增强扫描,其中A组79例采用减量稀释对比剂进行手推注射动态增强扫描,B组74例采用半剂量钆喷酸葡胺双筒高压注射器进行动态增强扫描,比较2组间垂体病变的检出率以及边界显示情况. 结果 志愿者中两种注射方法 垂体均见明显强化,均在约1min内达到强化峰值,乙组垂体强化程度高于甲组( P <0.05),垂体与海绵窦分界显示效果接近( P =0.085). 两组患者垂体病变的检出率( P =0 .787 )、垂体病变的边界显示效果( P =0 .682 )接近. 结论 手推注射减量稀释钆对比剂在垂体MRI动态增强扫描中的应用效果与采用高压注射半剂量对比剂效果相仿.