柴黄清胰活血颗粒治疗重症急性胰腺炎患者的疗效观察

摘要

Objective: To investigate the clinical effect of Chaihuang Qingyi Huoxue Granule on the treatment of patients with severe acute pancreatitis. Methods: A total of 60 patients with severe acute pancreatitis who were given conventional treatment in the department of gastroenterology, affiliated traditional chinese medicine hospital, southwest medical university were enrolled and randomly divided into experimental group and control group, with 30 patients in each group. The patients in the experimental group were given tube feeding or oral administration of Chaihuang Qingyi Huoxue Granule combined with enema, and those in the control group were given tube feeding or oral administration of Qingyi Lidan Granule combined with enema. The scores of symptoms and signs, serum amylase, white blood cell count, and response rate were recorded on admission and on days 3 and 7 after admission. Results:After treatment, both groups had significant improvements in the scores of symptoms and signs (P ＜0.05), with significantly lower scores on day 7 (P ＜ 0.05). After treatment, both groups had significant reductions in serum amylase and white blood cell count (P ＜ 0.05), and the experimental group had significantly greater reductions (P ＜ 0.05).The experimental group had a significantly higher response rate than the control group (93.3％ vs 73.3％, P ＜ 0.05).Conclusion: In patients with severe acute pancreatitis who receive conventional basic treatment, Chaihuang Qingyi Huoxue Granule can significantly reduce the scores of symptoms and signs, serum amylase level, and white blood cell count and increase the response rate, with a better clinical effect than Qingyi Lidan Granule.%目的:观察柴黄清胰活血颗粒治疗重症急性胰腺炎患者的临床效果.方法:从西南医科大学附属中医医院脾胃病科选取重症急性胰腺炎患者共60例,予以常规治疗后,随机分为试验组30例和对照组30例.两组分别加用柴黄清胰活血颗粒和清胰利胆颗粒管喂(或口服)和灌肠.记录入院时、第3、7 d的患者症状和体征量化评分、血清淀粉酶、白细胞计数以及有效率.结果:患者经治疗后症状、体征量化评分较入院时好转(P ＜0.05),第7 d试验组评分更低(P ＜0.05);患者入院经治疗后,血清淀粉酶和白细胞计数都降低(P ＜0.05);试验组降低更为明显(P ＜0.05).试验组有效率93.3％明显高于对照组有效率73.3％(P ＜0.05).结论:常规基础治疗重症急性胰腺炎患者时,加用柴黄清胰活血颗粒能显著降低患者症状、体征量化评分以及血清淀粉酶、白细胞计数,具有更高的有效率,且疗效优于清胰利胆颗粒.