目的：探讨不同麻醉药物对全麻苏醒期躁动（EA）的影响．方法将134例术后出现EA的患者随机分为A组（42例）、B组（45例）和C组（47例），术后分别采用帕瑞昔布40 mg、布托啡诺20μg/kg和曲马多1 mg/kg，静脉注射．比较各组治疗后躁动的改善程度、VAS评分及Ramsay镇静评分等．结果治疗后，A组、B组患者EA的程度显著低于C组（＜0.05）；治疗后，3组VAS评分显著下降，Ramsay镇静评分显著升高（＜0.05），其中C组VAS评分显著高于A组、B组，B组Ramsay镇静评分显著高于A组、C组（＜0.05）；治疗后，B组患者苏醒时间、PACU停留时间显著高于A组、C组（＜0.05）．结论帕瑞昔布治疗EA安全有效，可有效改善全身麻醉后EA患者的躁动程度，提高术后的镇静效果，缩短PACU停留时间．%Objective To explore the influence of different anesthetics on emergence agitation (EA) after general anesthesia. Methods 134 EA patients after general anesthesia were randomly divided into three groups. Group A (n=42), Group B (n=45) and Group C (n=47) was given intravenously parecoxib 40 mg, butorphanol 20μg/kg and tramadol 1 mg/kg, respectively. The improvement of agitation, VAS score and Ramsay score were compared and analyzed among the groups. Results After treatment, the degree of EA in Group A, Group B was significantly lower than that in Group C ( <0.05) . VAS score in all the cases was reduced, and Ramsay score was increased compared with that before treatment ( <0.05) . VAS score in Group C was significantly higher than that in Group A, Group B (<0.05) . Ramsay score in Group B was significantly higher than that in Group A, Group C (<0.05) . After treatment, awaking time and postanesthesia care unit (PACU) stay in Group B was significantly higher than that in Group A, Group C (<0.05) .Conclusions Parecoxib is safe and effective for EA after general anesthesia, it can effectively improve the degree of EA, increase postoperative sedative effect, and shorten PACU stay.
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