Effect of Toxic Threat Nerve Agents on Anesthetic Requirements of RepresentativePre-Anesthetic Medicants and Inhalant and Parenteral General Anesthetic in the Cat. (The Effect of Soman on Anesthetic Requirements in the Cat)

摘要

The effect of soman (8ug/kg) on anesthetic requirements of inhalant andparenteral anesthetic was studied in cats, using minimal alveolar concentration (MAC) and minimum infusion rate (MIR) indices of anesthetic requirement or potency. There were no significant effects on inhalant anesthetic (halothane, isoflurane, an enflurane) requirements; there was a small increase in ketamine anesthetic requirements 4 and 7 days after soman intoxication. Thiopental requirements were unaffected. The interaction of acepromazine, diazepam, droperidol and meperidine with inhalant anesthetic requirements was also studied. Only with droperidol and halothane was there any significant interaction. The premedicants were administered intramuscularly and the variable efficacy observed with diazepam and meperidine appears to possible relate to uptake of the drugs into the systemic circulation. Survival of clinically intoxicated cats was increased when they were anesthetized with enflurane. Similarly, cats subjected to thiopental anesthesia 8-5 days before administration of soman appeared to be protected against intoxication, while ketamine did not confer any protection. (JS)