云南汉族原发性高血压ACE基因多态性与厄贝沙坦降压疗效相关性

摘要

目的 探讨云南汉族原发性高血压(EH)患者ACE基因多态性与厄贝沙坦降压疗效相关性.方法 选择100例1～2级原发性高血压患者,PCR检测基因多态性,厄贝沙坦150 mg,每日1次降压治疗4周后评估降压疗效.结果 厄贝沙坦降压疗效在不同基因型中具有差异性,降压疗效DD型＞ID型＞Ⅱ型,差异有统计学意义(P＜0.05).结论 不同基因型对ARB药物治疗反应性具有差异性,基因多态性可能是影响个体对药物治疗反应的遗传因素.%Objective To analyze the correlationship of ACE I/D gene polymerphisms with the anti-hypertensive efficacy of irbesartan among essential hypertension (EH) patients in Yunnan han people.Methods One hundred EH patients hypertension were treated with irbesartan 150mg once daily for 4 weeks,and anti-hypertensive efficacy were monitored during the treatment.Results There was a significant difference between anti-hypertensive efficacy of irbesartan among different genotype groups,DD group ＞ID group ＞Ⅱ group (P ＜ 0.05) Conclusions There is different therapy responsiveness in diffenent genotypes.ACE I/D polymorphism may be an important hereditary factor that impacts the efficacy of irbesartan.