膝关节韧带组织损伤与修复的力学生物学研究进展

摘要

目的：膝关节前交叉韧带（anterior cruciate ligament，ACL）损伤是一种较常见的机械性损伤，韧带的撕裂或断裂都会造成膝关节不稳，长期损伤会导致膝关节退行性病变，甚至骨关节炎等并发症。当前临床治疗面临最大的挑战就是 ACL 修复能力较弱，损伤后不能像内侧副韧带一样能够自身功能性修复。除了 ACL组织本身存在的先天遗传性差异外，其损伤后关节腔微环境的变化可能是调节损伤的 ACL 修复的关键因素。%Objective Injury to the anterior cruciate ligament (ACL)causes knee instability,pain,and may re-sult in progressive degeneration and osteoarthritis.An injured ACL does not heal satisfactorily as compared to oth-er joint tissues such as medial collateral ligament (MCL),making it as one of the most challenging and intractable clinical problem today.Apart from these intrinsic differences,microenvironment in knee joint cavity also regulates the ligament's healing ability.