转化生长因子β(TGF-β)是一种能够调节细胞生长、分化及细胞外基质生成的生长因子.血管重塑是很多心血管疾病发生的共同病理过程,TGF-β能够诱导血管外膜成纤维细胞增生及其向肌成纤维细胞的表型转化,在血管损伤部位促进血管重塑等一系列改变.Smad蛋白参与TGF-β细胞内信号转导,通过与不同蛋白相结合形成复合体,调控TGF-β靶基因的表达,从而发挥多种生物学功能.本文就TGF-β对血管外膜成纤维细胞增殖、迁移和表型转化的影响进行综述.%Transforming growth factor p( TGF-p) is a growth factor regulating cell proliferation, differentiation and the production of extracellular matrix. Vascular remodeling is a common pathological process of many cardiovascular diseases. TGF-p can accelerate vascular adventitial fibroblasts proliferation, induce the transdifferentiation of vascular adventitial fibroblasts into myofibroblasts, and promote the vascular remodeling and a series of changes in vascular injury sites. Smad proteins involved in TGF-p intracellular signal transduction can regulate the expression of TGF-p target gene by binding with differenot proteins, so as to perform multiple biological functions. This review introduces the influence of TGF-p on the proliferation, migration and phenotype transformation of vascular adventitial fibroblasts.
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