急性冠脉综合征患者血浆中 NT-proBNP 和hs-CRP联合检测的应用价值

摘要

目的：检测急性冠脉综合征（ACS）患者血浆中氨基末端钠尿肽前体（NT-proBNP）和超敏CRP（hs-CRP）含量水平，以探讨其在ACS诊断及预后评估中的应用价值。方法将126例ACS患者作为观察组，58例健康体检者作为对照组；用放射免疫分析法和vitros ECi免疫发光法同时检测2组样本血浆中的hs-CRP和NT-proBNP含量水平，并采用t检验比较2组的x珋±s差异有无显著性，对NT-proBNP与hs-CRP水平关系运用Pearson相关性分析。结果ACS患者组血浆中的NT-proBNP和hs-CRP含量水平均显著高于对照组（P＜0．01），对NT-proBNP与hs-CRP浓度水平关系运用Pearson相关性分析，结果表明二者呈显著正相关（P＜0．05）。结论联合检测血浆中的NT-proBNP和hs-CRP含量水平，对ACS的诊断和预后评估具有较重要的价值。%Objective To investigate the levels of N-Terminal proB-Type natriuretic peptide ( NT-proBNP) and high-sen-sitivity C-reactive protein (hs-CRP) in plasma of patients with acute coronary syndrome (ACS),and to explore the clinical meanings.Methods 126 ACS patients were set as an observation group ,and 58 healthy adults as a control group .Radiation immunity analysis method and vitros ECi immune luminescence detection were applied simultaneously to detect the hs -CRP and the NT-proBNP levels in plasma of two sets of samples;x±s of the two groups were calculated respectively by using t test to compare differences .Pearson correlation analysis was conducted to analyze the relationship between the NT -proBNP and hs-CRP levels.Results In comparison with the normal controls ,the levels of NT-proBNP and hs-CRP were higher in ACS pa-tients.The difference was significant(P<0.01).The level of NT-proBNP was positively correlated with that of hs-CRP(P<0.05).Conclusion Combined detection of plasma levels of NT-proBNP and hs-CRP is of clinical value for the diagnosis and prognosis of ACS .