目的：评价经尿道膀胱癌电切术联合吡柔比星膀胱灌注治疗非肌层浸润膀胱癌临床疗效。方法：选取2012年3月－2014年6月收治的68例非肌层浸润膀胱癌患者作为观察对象，采取随机数字表法分为观察组（34例）和对照组（34例）。对照组采取经尿道膀胱癌电切术治疗，观察组在对照组治疗基础上联合吡柔比星膀胱灌注治疗，观察对比2组患者临床治疗效果、术后并发症情况，并进行为期1 a随访，观察2组患者复发情况。结果：总有效率，观察组为97.06％，对照组为85.29％，观察组高于对照组，差异具有统计学意义（ P＜0.05）；总并发症率：观察组为2.94％，对照组为14.71％，观察组明显低于对照组，差异具有统计学意义（ P＜0.05）；观察组未见复发病例，对照组1例复发，2组总复发率比较，差异无统计学意义（ P＞0.05）。结论：经尿道膀胱癌电切术联合吡柔比星膀胱灌注治疗非肌层浸润膀胱癌，临床效果良好，可显著提升治疗总有效率，降低术后并发症率，且复发率低，安全性较高。%Objective:To explore the clinical effect of transurethral resection of bladder tumor ( TURBT) combined with pirarubicin irrigation of bladder in treatment of non muscle-invasive bladder cancer.Methods:68 cases of non muscle-invasive bladder cancer pa-tients admitted from March 2012 to June 2014 were selected and randomly divided into an observation group and a control group, with 34 cases in each.The patients in the control group were treated with TURBT, while the patients in the observation group, on the basis of the former, were supplemented with therapy of pirarubicin irrigation of bladder.The two groups were observed and compared in terms of clinical effect and postoperative complications.Also the situation of disease recurrence was observed in a one year follow-up.Re-sults:After the treatment, the total effective rate of the observation group was 97.06%, while the rate was 85.29% for the control group, with the former higher than the latter.The difference was statistically significant(P<0.05).As for the complication rate, the treatment group was 2.94%, much lower than that of the control group's 14.71%.The difference had statistical significance(P<0.05 ) .No relapse occurred in the observation group, and one case was reported in the control group.There was no statistically signifi-cant difference (P>0.05).Conclusion:TURBT combined with pirarubicin irrigation of bladder in treatment of non muscle-invasive bladder cancer has a fine clinical effect.It can significantly improve treatment effect with the advantage of high safety and low rate of complication and recurrence.
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