阿托伐他汀强化方案对急性冠脉综合征患者血清炎症因子及血小板活性、纤溶活性的影响

摘要

目的：：观察阿托伐他汀强化方案对急性冠脉综合征(ACS)患者血清炎症因子及血小板活性、纤溶活性的影响.方法：将92例纳入研究的 ACS 病例非抽签分为治疗组(47例)和对照组(45例).对照组在常规治疗的基础上给予阿托伐他汀10 mg/d,观察组在常规治疗的基础上强化阿托伐他汀给药量,为40 mg/d.治疗半个月,观察两组 IL-6、IL-8、hs-CRP、TNF-α及 TXB2、GMP-140、PAI-1、t-PA 变化.结果：治疗半个月,两组炎症指标 IL-6、IL-1、CRP、TNF-α及血小板活性指标 TXB2、GMP-140、PAI-1均较治疗前明显下降(P ＜0．05),而纤溶指标 t-PA 较前上升,且观察组各指标变化幅度均大于对照组,各指标治疗后同期比较差异均有统计学意义(P ＜0．05).结论：在降低炎症因子水平、抑制血小板活性、纠正纤溶系统高凝状态方面,阿托伐他汀40mg/d 强化给药方案治疗 ACS 优于常规10mg/天给药.%Objective:To observe the effect of atorvastatin intensive therapyon serum inflammatory factors,platelet ac-tivity and fibrinolytic activity in patients with acute coronary syndrome (ACS).Methods:A total of 92 cases with ACS were randomly divided into observation group (47 cases)and control group (45 cases).The control group was given atorvastatin 10 mg/ d based on conventional treatment,and the observation group was given intensive therapy of atorvastatin,40 mg/d based on conventional treatment.For half a month,the changes of IL-6,IL-8,hs-CRP,TNF-αand TXB2,GMP-140,PAI-1,t-PA between the two groups were observed.Results:After treatment,inflammatory factors IL-6,IL-1,CRP,TNF-α and platelet activity index TXB2,GMP-140,PAI-1 were significantly decreased and fibrinolytic activity indexes were significantly increased after treatment (P <0.05),and all indexes of the observation group were improved more significantly than that of the control group (P <0.05).Conclusion:Intensive therapy administration of atorvastatin 40 mg/d has better effect than conventional dose 10 mg/d in the aspects of reducing inflammatory factors,inhibiting platelet activity and correcting the high coagulation state of fibrinolytic system.