Objective: To study the effect of bronchoscopic ambroxol lavage on inflammatory factors in lavage fluid of patients with bronchiectasis complicated by infection.Methods: A total of 100 patients with bronchiectasis complicated by infection who were treated in our hospital between May 2012 and January 2016 were divided into the control group (n=54) who received conventional treatment and the observation group (n=46) who received intravenous anti-infection combined with bronchoscopic ambroxol lavage after the therapies were reviewed.The contents of inflammatory factors, adhesion molecules and acute phase proteins in lavage fluid were compared between the two groups.Results: Before treatment, the differences in contents of inflammatory factors, adhesion molecules and acute phase proteins in lavage fluid were not statistically significant between two groups of patients (P>0.05).After treatment, inflammatory factors IL-4, IL-6, IL-10 and TNF-α contents in lavage fluid of observation group were lower than those of control group;adhesion molecules sICAM-1 and VCAM-1 contents in lavage fluid were lower than those of control group;acute phase proteins CRP, AAG, HPT and CER contents in lavage fluid were lower than those of control group (P<0.05).Conclusiosn: Bronchoscopic ambroxol lavage can reduce airway inflammation in patients with bronchiectasis complicated by infection.%目的:探讨支气管镜下氨溴索灌洗对支气管扩张并发感染患者灌洗液中炎症因子的影响.方法:选择在本院进行治疗的支气管扩张并发感染患者100例,回顾治疗方案并分为接受常规治疗的对照组患者54例、接受静脉抗感染联合支气管镜下氨溴索灌洗治疗的观察组患者46例.对比两组治疗前后灌洗液中炎症因子、黏附分子、急性时相蛋白含量的差异.结果:治疗前,两组患者灌洗液中炎症因子、黏附分子、急性时相蛋白含量的差异无统计学意义(P>0.05).治疗后,观察组患者灌洗液中炎症因子IL-4、IL-6、IL-10、TNF-α的含量低于对照组患者;灌洗液中黏附分子sICAM-1、VCAM-1的含量低于对照组患者;灌洗液中急性时相蛋白CRP、AAG、HPT、CER的含量低于对照组患者(P<0.05).结论:支气管镜下氨溴索灌洗可减轻支气管扩张并发感染患者的气道炎症.
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