降脂抗凝联合复方丹参滴丸对高血压合并颈动脉硬化患者内皮功能及血清生化指标的影响

摘要

目的:研究降脂抗凝联合复方丹参滴丸对高血压合并颈动脉硬化患者内皮功能及血清生化指标的影响.方法:选择在我院就诊的高血压合并颈动脉粥样硬化患者98例作为研究对象,随机分为接受降脂抗凝联合复方丹参滴丸治疗的研究组、常规降脂抗凝治疗的对照组.治疗4周后,测定血清中内皮损伤指标和脂质代谢指标.结果:治疗4周后,研究组患者血清中ET-1、TXB2、TC、LDL-C、ox-LDL、Lp(a)、瘦素、抵抗素、趋化素的含量均显著低于对照组,NO、6-Keto-PGF1α、HDL-C、脂联素、内脂素的含量均显著高于对照组.结论:降脂抗凝联合复方丹参滴丸能够改善高血压合并颈动脉硬化患者的内皮功能和脂质代谢.%Objective: To study the effect of lipid-lowering anticoagulant therapy combined with compound Danshen dropping pill on the endothelial function and serum biochemical indexes in patients with hypertension and carotid atherosclerosis.Methods: A total of 98 patients with hypertension and carotid atherosclerosis treated in our hospital between June 2014 and July 2016 were selected as the research subjects and randomly divided into the research group who received lipid-lowering anticoagulant therapy combined with compound Danshen and the control group who received conventional lipid-lowering anticoagulant therapy.After 4 weeks of treatment, endothelial injury indexes and lipid metabolism indexes in serum were determined.Results: After 4 weeks of treatment, serum ET-1, TXB2, TC, LDL-C, ox-LDL, Lp(a), leptin, resistin and chemerin levels of research group were significantly lower than those of control group while NO, 6-Keto-PGF1α, HDL-C, adiponectin and visfatin levels were significantly higher than those of control group.Conclusions: Lipid-lowering anticoagulant therapy combined with compound Danshen dropping pill can improve the endothelial function and lipid metabolism in patients with hypertension and carotid atherosclerosis.