降脂抗凝降压药物联合银杏胶囊对颈动脉硬化患者内皮损伤、斑块稳定性的影响

摘要

Objective:To investigate the effects of lipid-lowing anticoagulant antihypertensive drugs combined with ginkgo capsule on endothelial injury and plaque stability in patients with carotid atherosclerosis.Methods:114 patients with ca-rotid atherosclerosis who were treated in Songzi People's Hospital between April 2016 and January 2017 were collected and di-vided into control group(n=57)and ginkgo capsule group(n=57)by random number table.Control group received conven-tional lipid-lowing anticoagulant antihypertensive drug therapy and ginkgo capsule group received lipid-lowing anticoagulant an-tihypertensive drugs combined with ginkgo capsule therapy.The differences in endothelial injury and plaque stability were com-pared between the two groups before and after treatment.Results:There was no statistically significant difference in serum lev-els of endothelial function indexes and plaque stability-related indexes between the two groups before treatment.After 1 month of treatment and after 6 months of treatment,serum endothelial injury indexes sVCAM-1,vWF and ET-1 levels of ginkgo cap-sule group were lower than those of control group at corresponding points in time whereas NO and 6-Reto-PGF1α levels were higher than those of control group at corresponding points in time;serum plaque stability-related indexes LEP,RETN,Hcy, PTX3 and Lp-PLA2 levels were lower than those of control group at corresponding points in time whereas APN levels were higher than those of control group at corresponding points in time.Conclusion:Lipid-lowing anticoagulant antihypertensive drugs combined with ginkgo capsule therapy can effectively protect the vascular endothelial function and stabilize the atheroscle-rotic plaque in patients with carotid atherosclerosis.%目的:探讨降脂抗凝降压药物联合银杏胶囊对颈动脉硬化患者内皮损伤、斑块稳定性的影响.方法:收集在本院康复科接受治疗的颈动脉硬化患者114例,经随机数表法分为对照组、银杏胶囊组各57例.对照组患者接受常规降脂抗凝降压药物治疗,银杏胶囊组患者在降脂抗凝降压治疗基础上加入银杏胶囊治疗.对比两组患者治疗前后内皮损伤、斑块稳定性的差异.结果:治疗前,两组血清中内皮功能指标、斑块稳定性相关指标含量的差异无统计学意义.治疗1月后、治疗6月后,银杏胶囊组血清中内皮损伤指标sVCAM-1、vWF、ET-1的含量低于对照组相应时间点,NO、6-Reto-PGF1α的含量高于对照组相应时间点;血清中斑块稳定性相关指标LEP、RETN、Hcy、PTX3、Lp-PLA2的含量低于对照组相应时间点,A PN的含量高于对照组相应时间点.结论:颈动脉硬化患者接受降脂抗凝降压药物联合银杏胶囊治疗,可有效保护血管内皮功能并稳定粥样斑块.