甲基丙烯酸在生物相容性微球CPVA表面的引发接枝聚合

摘要

交联聚乙烯醇（CPVA）微球表面含有大量的羟基，具有良好的生物相容性。在水溶液体系中利用这些羟基，与铈盐构成氧化还原引发体系，实施了甲基丙烯酸（MAA）的表面引发接枝聚合，制备了接枝微球CPVA—g—PMAA，考察了主要因素对接枝聚合的影响。采用红外光谱（FT—IR）及扫描电子显微镜（SEM）对接枝微球进行了表征。结果表明，羟基-铈盐氧化还原引发体系可有效地引发MAA在CPVA微球的表面接枝聚合，当铈盐浓度为4．9×101mol／L、硫酸浓度为0．17mol／L、反应温度为45。C、单体浓度为0．54mol／L时，每1。0g接枝微球CPVA—g—PMAA可接枝PMAA30g。%Crosslinked polyvinyl alcohol （CPVA） microspheres were a class of polymer microspheres with biocompatibility. A redox initiation system was constructed with a great deal of hydroxyl group on CPVA microspheres and cerium ammonium sulfate. The surface-initiated graft polymerization of methacrylic acid （MAA） was performed in an aqueous solution, making for the grafted microspheres CPVA-g-PMAA. The main influence factors on the graft polymerization were explored. The chemical structure and phy- sicochemistry characters were adequately characterized by infrared spectrum （FT-IR） and scanning electron microscope （SEM）. Results show that hydroxyl group-cerium salt redox initiation system can effectively initiate the graft polymerization of MAA on CPVA microspheres. When the cerium salt concentration was 4.9）〈 10 3 mol/L, the sulfuric acid concentration was 0.17 mol/L, the MAA concentration was 0.54 mol/ L, the 100 g grafted microspheres CPVA-g-PMAA with a PMAA grafting degree of 30 g can be prepared at 45 ℃.