夜间不明原因猝死综合征和阻塞性睡眠呼吸暂停低通气综合征关系的研究进展

摘要

Sudden unexplained nocturnal death syndrom e (SU N D S ) is alw ays a difficulty in forensic m edicine researches. A lthough the developm ent of m olecular genetics prom otes the etiologic study of SU N D S, the pathogenesis of m ost such cases is still unclear. Sleep apnea syndrom e (SA S) is one of the com m on form s of sleep disorders, and obstructive sleep apnea hypopnea syndrom e (O SA H S ) is the m ost com m on. In recent years, som e dom estic and international researches show that O SA H S is related to the developm ent of cardiovascular disease, w hich m ay cause cardiac arrhythm ia, even sudden death. T his article review s the relationship betw een SU N D S and O SA H S and aim s to provide new ideas for the pathogenesis of SU N D S.%夜间不明原因猝死综合征一直是法医学研究的难点,近年来分子遗传学的发展促进了其病因学研究,但仍有大部分案例病因不明.睡眠呼吸暂停综合征是一种常见的睡眠障碍性疾病,其中以阻塞性睡眠呼吸暂停低通气综合征最为常见.近年来,国内外研究表明阻塞性睡眠呼吸暂停低通气综合征与心血管疾病的发生密切相关,可以导致心律失常甚至引起猝死.本文主要综述了夜间不明原因猝死综合征与阻塞性睡眠呼吸暂停低通气综合征之间的关系,从而为不明原因猝死的发病机制提供新的思路.