ABSTRACT:At present, it is an important way to study the development of natural medicine via searching for active substances from marine life. Squid is an abundant marine animal and its ink is wastes from squid processing. However, Squid ink is a kind of marine active substance with great potential on its physiological activities, such as hemostasis, antibacterial, enhance immunity, antitumor and antioxidation. Squid ink polysaccharide is the most important active ingredient isolated from squid ink, which has good effects of antioxidant, antitumor, antichemotherapy and enhanced immunity, etc. The researches on bioactive constituents in squid ink provide not only high value utilization way for squid processing wastes, but also new resources for development of clinical medicine and health food, which demonstrate great significance to expand the source of medicine and make full use of marine resources, thus, attract the extensive attention from scientific researchers. In this review, we summarized the recent research progress about squid ink and its polysaccharide at home and abroad, in terms of their physical and chemical properties, biological activity and clinical application, and proposed the future research direction according to their research characteristic and application prospects.%目前，从海洋生物中寻找活性物质，是研究开发天然药物的一个重要方向。乌贼是丰富易得的海洋生物，而乌贼墨是乌贼加工中的废弃物，它作为一种极具潜力的海洋活性物质，具有止血、抗菌、增强免疫、抗肿瘤、抗氧化等多种生理活性。乌贼墨多糖就是从乌贼墨中分离出的一种主要活性成分，在抗氧化、抗肿瘤、抗化疗、增强免疫等功能活性方面均表现出了良好的作用效果。通过对乌贼墨中生物活性成分的研究，不仅为乌贼加工废弃物提供了高值化利用途径，也为开发临床医药、保健食品提供了新的资源，对扩大药源及对海洋资源的充分利用都具有深远意义，已受到科研工作者的广泛关注。本文通过综合近年来国内外有关乌贼墨及其活性多糖的研究进展，对它们的理化性质、生物活性和临床应用等方面进行了较为系统的综述，并根据其研究特点和应用前景提出了未来研究的发展方向。
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