Objective To investigate the clinical efficacy of phenobarbital combined with ganglioside in the treatment of neonatal hypoxic ischemic encephalopathy. Methods A total of 82 newborns with neonatal hypoxic ischemic encephalopathy were randomly divided into control group (n = 41) and observation group (n =41). The control group received routine treatment,while the observation group received phenobarbital combined with ganglioside based on the treatment in the control group. The blood concentration of phenobarbital was monitored and the'clinical effects of the two groups were compared. Results The total efficacy rate in the observation group (90.2% ) was significantly higher than that in the control group (63. 4%) after treatment. When phenobarbital plasma concentration of newborns in the observation group increased,clinical efficacy first increased and then decreased. When the phenobarbital plasma concentration was 25-40 μg/mL,the total efficiency went up to 94.7 %. Conclusion Phenobarbital combined with ganglioside in the treatment of neonatal hypoxic ischemic encephalopathy has obvious effect,which can improve the clinical symptoms of newborns. It' s a safe and effective method,which is worthy of clinical application. When phenobarbital plasma concentration is 25 - 40 μg/mL,the treatment efficacy reaches its best.%目的 探讨苯巴比妥联合神经节苷脂治疗新生儿缺氧缺血性脑病的临床疗效.方法 将82例新生儿缺氧缺血性脑病患儿随机分为2组.采用常规治疗的41例患儿作为对照组,在对照组基础上使用苯巴比妥联合神经节苷脂治疗的41例患儿为观察组.监测观察组苯巴比妥血药浓度,并比较2组临床疗效.结果 治疗后观察组总有效率(90.2％)明显高于对照组(63.4％).观察组患儿随着苯巴比妥的血药浓度增加,临床疗效呈现出先增强后减弱的趋势,苯巴比妥的血药浓度为25～40 μg/mL时,总有效率最高为94.7％.结论 采用苯巴比妥联合神经节苷脂治疗新生儿缺氧缺血性脑病的临床疗效显著,可以明显改善患儿的临床症状,是一种安全有效的治疗方法,值得临床推广使用.苯巴比妥的血药浓度为25～40 μg/mL时治疗效果最佳.
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