IMMUNOTHERAPEUTIC COMBINATIONS FOR THE TREATMENT OF TUMORS THAT OVER-EXPRESS GANGLIOSIDES

摘要

The invention relates to the field of immunology and specifically toimmunotherapeutic combinations that are used to impede the growth of tumourcells and/or to eliminate said cells. The present invention can be used toobserve a therapeutic antitumour effect by combining idiotypic vaccines havingan antiganglioside antibody (Ab1) as the active principle thereof withidiotypic vaccines, the active principle of which is an anti-idiotype antibodyobtained against an antiganglioside antibody (Ab2), or with vaccines, theactive principle of which is one or more gangliosides. The invention relatesto combinations of said vaccines which produce a synergism of the antitumoureffect which is induced separately by each of the vaccines. Said combinationscan be applied to patients in different clinical states with tumours thatoverexpress gangliosides.