Hepatitis B virus exists in human body as quasispecies. The interactions among viral clones might influence its characteristics and functions. The investigation of the correlation between viral heterogeneity and the anti - viral response might provide important evidences for personalized anti - viral treatment.%乙型肝炎病毒在人体内以准种形式存在,病毒株之间的相互作用可能影响其特性及功能.应用相关技术从病毒异质性角度探讨与抗病毒药物治疗应答相关性,可能为个体化抗病毒治疗提供重要依据.
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