ER、PR、Ki-67表达与子宫内膜癌发生的相关性研究

摘要

Objective To research Ki-67,PR and ER expression of pathological tissues of patients with endometrial carcinoma and the clinical value. Methods 60 patients with dometrial carcinoma( the canceration group),60 patients with typical hyperplasia of endometrium( the typical hyperplasia group)and 60 patients with atypical hyperplasia( the atypical hyperplasia group)were selected. Immunohistochemical was applied to detect ER,PR and Ki-67 expression of three groups,and the relationship between the indicators and clinical pathological feature of endometrial cancer was observed. Results The positive expression of ER and PR of the canceration group was evidently lower than that of the oth-er two groups,and Ki-67 expression was evidently higher than that of the other two groups,which had evident difference( P ﹤0. 05). The ex-pression rate of ER and PR for the I stage was evidently higher than that for the II stage and the III stage( P ﹤0. 05). The positive expression rate of ER and PR of well-differentiated tissues was evidently higher than that of the medium and the low differentiated tissues( P ﹤0. 05). And the positive expression rate of Ki-67 of well-differentiated tissues was evidently lower than that of the medium and low tissues( P ﹤0. 05). PR ex-pression of tissues without muscular infiltration canceration was evidently higher than that with superficial muscular infiltration and deep muscular infiltration( P ﹤0. 05). Ki-67 expression of tissues with lymphatic metastasis was evidently higher than that without lymphatic metastasis( P ﹤0. 05). Conclusion ER,PR and Ki-67 have correlation with the incidence of endometrial cancer,and the indexes can reflect the degree of canceration and clinical prognosis to some extent. And detecting ER,PR and Ki-67 expression can provide effective reference for targeted treat-ment scheme of endometrial cancer.%目的：探讨子宫内膜癌患者病理组织中的细胞增殖核抗原（ Ki-67）、孕激素受体（ PR）和雌激素受体（ ER）表达及其临床价值。方法选取60例子宫内膜癌患者（癌变组）以及子宫内膜典型增生组（典型增生组）60与非典型增生组60例（非典型增生组）。采用免疫组化法检测三组ER、PR、Ki-67表达情况，并观察各指标与子宫内膜癌临床病理特征的关系。结果癌变组患者ER、PR阳性表达均明显低于其他两组，Ki-67表达均明显高于其他两组，差异均有显著性（ P ﹤0.05）。分期为Ⅰ期的ER、PR表达率均明显高于Ⅱ、Ⅲ期（ P ﹤0.05）。高分化ER、PR阳性表达率均明显高于中、低分化组织（ P ﹤0.05），高分化Ki-67阳性表达率明显低于中、低期（ P ﹤0.05）。无肌层浸润癌变组织的PR表达明显高于浅肌层浸润以及深肌层浸润组织（ P ﹤0.05）。有淋巴结转移组织的Ki-67表达均明显高于无淋巴结转移（ P ﹤0.05）。结论 ER、PR、Ki-67均与子宫内膜癌的疾病发生存在相关性，可以在一定程度上反映癌变的程度以及临床预后，检测ER、PR、Ki-67表达可以为子宫内膜癌靶向治疗方案提供有效的依据。