子宫内膜癌临床病理因素与ER、PR、p53、Ki-67相关性研究

摘要

目的 探究ER、PR、p53、Ki-67表达与子宫内膜癌临床病理因素之间的相关性.方法 本研究选取2014年6月1日至2016年6月30日期间在本院进行治疗的156例子宫内膜癌患者作为研究对象,并对其临床信息、免疫组织化学结果以及组织病理信息进行分析.结果 手术病理分期与ER、PR的阳性表达之间呈负相关,与p53、Ki-67的阳性表达呈正相关,ER、PR以及P53的阳性表达与其子宫内膜癌中各分期表达均有显著性差异,P<0.05.ER、PR以及P53的阳性表达在子宫内膜腺癌与非腺癌之间的表达率具有统计学价值,P<0.05.在腺癌中,ER、PR显著表达,在非腺癌中,p53显著表达,其表达率均有统计学价值.但Ki-67的阳性表达在两种病理类型中的并无显著性差异,P>0.05.结论 ER、PR、p53、Ki-67的异常表达可作为子宫内膜癌患者临床诊断,指导患者临床治疗方案以及判断其预后情况的主要依据.%Objective To investigate the correlation between the expression of ER, PR, p53, Ki-67 and clinical pathological factors of endometrial carcinoma.Methods From June 1st, 2014to June 30th, 2016, 156 cases of endometrial carcinoma patients treated in our hospital were chose as the research objects, and the clinical information, the results of immunohistochemistry and pathological information were analyzed.Results The positive expression of ER and PR was negatively related with surgical pathological staging, the positive expression of Ki-67 and P53 was positively correlated with it.The positive expression of ER, PR and P53 in endometrial carcinoma were different in each stage,P<0.05.The positive expression rates of ER, PR and P53 were statistically different in endometrial adenocarcinoma and adenocarcinoma tissue,P<0.05.The expression of ER and PR was significantly increased in adenocarcinoma, and the expression of P53 was significantly higher in adenocarcinoma.However, there was no significant difference in the positive expression of Ki-67 in two pathological types,P>0.05.Conclusions The abnormal expression of ER, PR, p53 and Ki-67 can be used as a clinical diagnosis of endometrial cancer patients, to guide the clinical treatment of patients and to be the main basis to determine the prognosis.