compound, methods of manufacturing the same, for treating or preventing a disease, for activating er function in a bone cell, for inhibiting er function in a cell, for inhibiting il-6 expression, for inhibiting growth of an er-expressing neoplastic cell, for prevention of spermatogenesis, for prevention of an adverse reproductive effect associated with exposure to a lack of natural or chemically environmental hormonal balance, and, composition

摘要

"COMPOSITE, METHODS FOR MANUFACTURING THE SAME, FOR TREATMENT OR PREVENTION OF A DISEASE, FOR ACTIVATION OF ER FUNCTION IN A BONE CELL, FOR INHIBITION OF ER FUNCTION IN A CELL, FOR INHIBITION OF THE EXPRESSION FOR ILL-INITION, 6 GROWTH OF A NEOPLASIC CELL EXPRESSING ER, FOR PREVENTION OF SPERMATOGENESIS, FOR PREVENTION OF AN ADVERSE REPRODUCTIVE EFFECT ASSOCIATED WITH EXPOSURE TO A LACK OF NATURAL OR CHEMICAL ENVIRONMENTAL, AND "COMPOSITION". Benzopyranone compounds having the following structure: wherein R 1, R 2, X, Y and n are as defined herein are described. Benzopyranone compounds are usable for the treatment or prevention of a bone resorption disease, a neoplastic disease, arthritis, an estrogen-exacerbated disease, or an estrogen-enhanced disease, comprising administering an effective amount of a compound. benzopyranone to a patient in need of treatment or prevention; activation of estrogen receptor ('ER') function in a bone cell; inhibition of ER function in a cancer cell; inhibition of interleukin-6 ('IL-6') expression in a cell; and inhibiting the growth of a neoplastic cell, comprising contacting the cell with an effective amount of a benzopyranone compound.